By the time a baby is born, its brain is equipped with billions of intricately crafted neurons wired together through trillions of interconnections to form a compact and breathtakingly efficient supercomputer. Zero to Birth takes you on an extraordinary journey to the very edge of creation, from the moment of an egg鈥檚 fertilization through each step of a human brain鈥檚 development in the womb鈥攁nd even a little beyond.
As pioneering experimental neurobiologist W. A. Harris guides you through the process of how the brain is built, he takes up the biggest questions that scientists have asked about the developing brain, describing many of the thrilling discoveries that were foundational to our current understanding. He weaves in a remarkable evolutionary story that begins billions of years ago in the Proterozoic eon, when multicellular animals first emerged from single-cell organisms, and reveals how the growth of a fetal brain over nine months reflects the brain鈥檚 evolution through the ages. Our brains have much in common with those of other animals, and Harris offers an illuminating look at how comparative animal studies have been crucial to understanding what makes a human brain human.
An unforgettable chronicle of one of nature鈥檚 greatest achievements, Zero to Birth describes how the brain鈥檚 incredible feat of orchestrated growth ensures that every brain is unique, and how breakthroughs at the frontiers of science are helping us to decode many traits that only reveal themselves later in life.
W. A. Harris is professor emeritus of anatomy at the University of Cambridge. A fellow of the Royal Society, he is the coauthor of Development of the Nervous System and Genetic Neurobiology and the coeditor of Retinal Development.
"Using an expository style, interspersed with first-person accounts of his own research, Harris provides an authoritative synopsis of developmental neuroscience."鈥擱. Douglas Fields, Science
"[Zero to Birth] really is a masterpiece in terms of how much information is packed into this average sized book."鈥擭icole Barbaro, Bookmarked Reads
"The story of how this development takes place is filled with as much drama as any Shakespearian plot. There are accounts of self-love and selfless cooperation, suicide and cannibalism, rivalry and survival of the fittest. All on the cellular level. And, fortunately for readers who are not experts in the field, the style makes the story comprehensible and engaging."鈥擥unnel Minett, Breathwork Science
"Highly illuminating."鈥擜ndrew Robinson, Nature
鈥淗arris鈥檚 engaging account of human brain development moves with dispatch through the key experiments in the field. His tone is warm and welcoming as he shares his wonder at discoveries already made and his optimism about those still to come. Harris captures the excitement, dare I say joy, of these discoveries in a way that is accessible to all readers.鈥濃擲usan E. Fahrbach, author of Developmental Neuroscience
鈥淒uring the past hundred years, developmental biologists have discovered many of the astonishingly cunning and counterintuitive secrets of how a mere fertilized egg develops into a baby with all its immense numbers of parts in all the right places. This is the magical story Harris tells in this authoritative book.鈥濃擯atricia S. Churchland, author of Braintrust: What Neuroscience Tells Us about Morality
鈥淗arris takes readers on a journey across space and time in the unfolding multiverse inside the fetal head. Combining humor with state-of-the-art science, he tells the stories of the scientists who pushed the frontiers of our understanding and crafts a tale that conveys extensive knowledge and leaves you smiling.鈥濃擬oriah E. Thomason, New York University Grossman School of Medicine